English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/79615
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

North African Populations Carry the Signature of Admixture with Neandertals

AuthorsSánchez-Quinto, Federico ; Botigué, Laura R.; Civit, Sergi; Arenas, Conchita; Ávila-Arcos, María C.; Bustamante, Carlos D.; Comas, David ; Lalueza-Fox, Carles
Issue Date17-Oct-2012
PublisherPublic Library of Science
CitationPLoS ONE 7(10): e47765 (2012)
AbstractOne of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient population substructure. Thus, the study of North African populations is crucial for testing both hypotheses. We analyzed a total of 780,000 SNPs in 125 individuals representing seven different North African locations and searched for their ancestral/derived state in comparison to different human populations and Neandertals. We found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans. This excess is similar to that found in non-African humans, a fact that can be interpreted as a sign of Neandertal admixture. Furthermore, the Neandertal's genetic signal is higher in populations with a local, pre-Neolithic North African ancestry. Therefore, the detected ancient admixture is not due to recent Near Eastern or European migrations. Sub-Saharan populations are the only ones not affected by the admixture event with Neandertals. © 2012 Sánchez-Quinto et al.
Publisher version (URL)http://dx.doi.org/10.1371/journal.pone.0047765
URIhttp://hdl.handle.net/10261/79615
DOI10.1371/journal.pone.0047765
Identifiersdoi: 10.1371/journal.pone.0047765
issn: 1932-6203
e-issn: 1932-6203
Appears in Collections:(IBE) Artículos
Files in This Item:
File Description SizeFormat 
north_african _Quinto.pdf581,13 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.