Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/79526
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | N-2-(Azol-1(2)-yl)ethyliminodiacetic acids: A novel series of Gd(III) chelators as T2 relaxation agents for magnetic resonance imaging |
Autor: | Álvarez, José; Cerdán, Sebastián CSIC ORCID; Ballesteros, Paloma CSIC ORCID | Fecha de publicación: | 1999 | Editor: | Elsevier | Citación: | Bioorganic and Medicinal Chemistry 7(3): 517-527 (1999) | Resumen: | The synthesis, physicochemical properties, and toxicological implications of a novel series of N-2-(azol-1(2)-yl)ethyliminodiacetic acids, useful as contrast agents for magnetic resonance imaging are reported. Compounds were prepared by alkylation of methyl iminodiacetate with N-2-bromoethylazoles and subsequent hydrolysis. Stability constants of the corresponding Gd(III) complexes and T1 and T2 relaxivities were determined and interpreted in terms of optimized geometries obtained by semiempirical PM3 calculations. Compounds show increased T2 relaxivity and decreased toxicity in vitro as compared to EDTA-Gd(III) complexes. Copyright (C) 1999 Elsevier Science Ltd. | URI: | http://hdl.handle.net/10261/79526 | DOI: | 10.1016/S0968-0896(98)00273-9 | Identificadores: | doi: 10.1016/S0968-0896(98)00273-9 issn: 0968-0896 e-issn: 1464-3391 |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
22
checked on 22-abr-2024
WEB OF SCIENCETM
Citations
23
checked on 29-feb-2024
Page view(s)
331
checked on 24-abr-2024
Download(s)
108
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.