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Título: | Ehrlich ascites tumor cells produce a transforming growth factor-β (TGFβ)-like activity but lack receptors with TGFβ-binding capacity |
Autor: | Elexpuru, Ana; Martín-Nieto, José; Jiménez, Amparo CSIC; Gómez, Carmen; Villalobo, Antonio CSIC ORCID | Fecha de publicación: | 1997 | Editor: | Springer Nature | Citación: | Molecular and Cellular Biochemistry 170(1-2): 153-162 (1997) | Resumen: | Ehrlich ascites tumor cells incorporate [methyl-3H]thymidine into DNA independently of exogenous growth factors or fetal calf serum. Using an acid/ethanol extraction procedure we have obtained from these tumor cells a fraction that induces both the proliferation and the formation of cell foci by Swiss 3T3 mouse fibroblasts in the presence of insulin; inhibits the proliferation of Mv1Lu mink lung epithelial cells; and stimulates the growth of NRK rat kidney fibroblasts in soft-agar in the presence of epidermal growth factor. An antibody against transforming growth factor-β (TGFβ) prevents both the tumor extract-induced proliferation of Swiss 3T3 fibroblasts and the tumor extract-induced proliferative arrest of Mv1Lu cells. The tumor cells secrete a TGFβ-like activity to the extracellular medium in a partially-activated form. However, authentic TGFβ does not affect their proliferation, and no TGFβ receptors were detected using [125I]TGFβ as a ligand. Therefore, the absence of TGFβ receptors with ligand-binding capacity in these tumor cells may bypass the negative control that this factor exerts on the proliferation of their normal cell counterparts. | URI: | http://hdl.handle.net/10261/79232 | DOI: | 10.1023/A:1006809604193 | Identificadores: | doi: 10.1023/A:1006809604193 issn: 0300-8177 e-issn: 1573-4919 |
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