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Título: | Glycosyl-phosphatidyl inositol-phospholipase type D: A possible candidate for the generation of second messengers |
Autor: | Jones, David R.; Ávila, Matías A. CSIC ORCID; Sanz, Carmen CSIC ORCID; Varela-Nieto, Isabel CSIC ORCID | Fecha de publicación: | 1997 | Editor: | Elsevier | Citación: | Biochemical and Biophysical Research Communications 233(2): 432-437 (1997) | Resumen: | Membrane associated glycosyl-phosphatidylinositols have been shown to be the precursors of inositol phosphoglycan second messengers. Extraction of human liver membranes and purification by serial thin layer chromatography revealed three glycolipids which co-migrated with glycosyl-phosphatidylinositol from rat liver. These lipidic fractions were partially sensitive to treatment with nitrous acid and to hydrolysis by glycosyl-phosphatidylinositol-specific phospholipase D from bovine serum. In parallel, glycosylphosphatidylinositol isolated from rat liver was found to be a substrate for the enzyme generating a biologically active inositol phosphoglycan species (determined by measuring inhibition of protein kinase A activity and stimulation of cell proliferation within the chicken embryo cochleovestibular ganglion). This molecule was recognised by an anti-inositol phosphoglycan antibody. Hence, we propose that glycosyl-phosphatidylinositol-specific phospholipase D could be implicated in cellular signalling. | URI: | http://hdl.handle.net/10261/79156 | DOI: | 10.1006/bbrc.1997.6475 | Identificadores: | doi: 10.1006/bbrc.1997.6475 issn: 0006-291X e-issn: 1090-2104 |
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