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Epidermal growth factor inhibits cytokine-dependent nitric oxide synthase expression in hepatocytes

AuthorsTerenzi, Fulvia; Casado, Marta ; Martín-Sanz, Paloma ; Boscá, Lisardo
Issue Date1995
CitationFEBS Letters 368(1): 193-196 (1995)
AbstractLiver cells express a wide range of extracellular receptors involved in the control of cell growth and arrest that can be studied ex vivo. Incubation of primary cultures of hepatocytes with IL-1β, TNF-α or lipopolysaccharide promotes the expression of the inducible form of nitric oxide synthase and NO release, a process that is inhibited to a different extent by incubation of the cells with EGF. In addition to this growth factor, IL-6 and TGF-β also inhibited NO synthesis. Therefore, EGF by itself or in combination with other cytokines may be involved in the downregulation of the NO synthesis that occurs in the early steps of liver regeneration.
Identifiersdoi: 10.1016/0014-5793(95)00646-Q
issn: 0014-5793
e-issn: 1873-3468
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