Antidepressant efficacy of Cb1 agonist Hu-210 in mice following chronic administration is not dependent on constitutive neurogenesis

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Campo DC	Valor	Lengua/Idioma
dc.contributor.author	Díaz, Álvaro	-
dc.contributor.author	Pazos, Ángel	-
dc.contributor.author	Blanco, Helena	-
dc.contributor.author	Valdizán, Elsa M.	-
dc.date.accessioned	2013-07-01T08:16:33Z	-
dc.date.available	2013-07-01T08:16:33Z	-
dc.date.issued	2012	-
dc.identifier.citation	8th Fens Forum of Neuroscience (2012)	-
dc.identifier.uri	http://hdl.handle.net/10261/78832	-
dc.description	Trabajo presentado al: "8th Fens Forum of Neuroscience" celebrado en Barcelon del 14 al 18 de julio de 2012.-- et al.	-
dc.description.abstract	Research has shown antidepressant/anxiolytic efficacy of acute cannabinoid treatment on preclinical tests. However, the behavioral effects of chronic cannabinoid administration in animal models of depression are still unknown. In the present study we have used the animal model of chronic administration of corticosterone in mice (35 μg/ml, 28days, oral ) in order to evaluate: a)the effect of chronic administration of the cannabinoid agonist HU-210 (25 μg/kg/day, i.p. 2weeks) in tests assessing anxiety- and depressive-like responses, and spatial short term memory; and b) the influence of constitutive neurogenesis on behavioral effects of HU-210, using a transgenic mouse in which ablation of glial fibrillary acidic protein (GFAP)-positive cells (thus eliminating adult neural progenitor cells) was induced by ganciclovir. Corticosterone-treated mice exhibited an anxiogenic response in the novelty-suppressed feeding (NSF, latency to feed=323.1±59.5 vs 137±14.3 seconds in control group; p< 0.01) and a depressive-like response in the sucrose preference test (>anhedonia>; %sucrose intake/total= 50.8±5.7 vs. 90.8±1.3 in control; p< 0.01). An impaired performance in the T-maze test (short-term spatial memory) was also shown in corticosterone-treated animals (%alternance= 49.7±2.7 vs 63.1±2.5 in control; p< 0.05). Chronic HU-210 reversed anxiety- (NSF, latency to feed= 174.5±30.8s; p< 0.01 vs corticosterone) and depressive-like (%sucrose=78.9±3.1%; p< 0.01 vs corticosterone) behaviors but not the impaired short term spatial memory. These effects of chronic HU-210 in the NSF (latency to feed=123.3±19.9s; p< 0.01 vs corticosterone) and sucrose (% sucrose= 78.8±1.8; p< 0.01 vs corticosterone) paradigms were still present in transgenic animals treated with chronic corticosterone. This is the first study demonstrating the anxiolytic and antidepressant actions of chronic HU-210 in a validated animal model of depression/anxiety. Our results in transgenic animals also indicate that constitutive neurogenesis might not be necessary for the behavioral effects of HU-210 in this animal model.	-
dc.description.sponsorship	Supported by CYCIT SAF07/61862 and FMM de Investigación.	-
dc.language.iso	eng	-
dc.rights	closedAccess	-
dc.title	Antidepressant efficacy of Cb1 agonist Hu-210 in mice following chronic administration is not dependent on constitutive neurogenesis	-
dc.type	póster de congreso	-
dc.date.updated	2013-07-01T08:16:34Z	-
dc.description.version	Peer Reviewed	-
dc.type.coar	http://purl.org/coar/resource_type/c_6670	es_ES
item.grantfulltext	none	-
item.cerifentitytype	Publications	-
item.openairecristype	http://purl.org/coar/resource_type/c_18cf	-
item.languageiso639-1	en	-
item.fulltext	No Fulltext	-
item.openairetype	póster de congreso	-
Aparece en las colecciones:	(IBBTEC) Comunicaciones congresos