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ABCB1_3435C>T AND ABCB1_2677G>T polymorphisms and pharmacoresistance of epilepsy: differences between children and adults

AuthorsSánchez, M. Blanca; Herranz, José L.; Leno, Carlos; Arteaga, Rosa; Oterino, Agustín; Valdizán, Elsa M. ; Nicolás, José M.; Adin, Javier; Rodríguez-Dichico, G. P.; Armijo, Juan A.
Issue Date2009
CitationEACPT 2009
AbstractChildren and adults differ in the kind of epilepsy and in the anticonvulsants used. The aim of this study was to analyze the association between ABCB1_3435C>T and ABCB1_2677G>T polymorphisms and pharmacorresistance in epileptic patients stratified into children and adults groups. Two hundred and eighty-nine caucasian epileptic patients, 80 children (£12 years) and 209 adults (>12 years), attending Neuropediatrics and Neurology Services at the Marqués de Valdecilla University Hospital were selected when they had either drug resistance (occurrence of at least four seizures over the year before recruitment with trials of more than three appropriate antiepileptic drugs at appropriate doses) or drug responsiveness (complete freedom from seizures for at least a year). Samples were genotyped by Applied Biosystems Genotyping Assays with TaqMan probes. Association was evaluated by stratified bivariate analysis using contingency tables. The pharmacoresistance risk in patients with the ABCB1_3435TT genotype was lower than in those with the CC genotipe in adults (OR: 0.40, 95%CI: 0.19-0.86, P = 0.019) but higher in children (OR: 4.22, 95%CI: 0.98-18.12), with a significant interaction between age and polymorphism (P = 0.015). Furthermore, the pharmacoresistance risk in patients with the ABCB1_2677TT genotype was lower than in those with the GG genotipe in adults (OR: 0.41, 95%CI: 0.18-0.92) but higher in children (OR: 4.17, 95%CI: 1.13-15.33), with a significant interaction between age and polymorphism (P = 0.006). ABCB1_3435TT and ABCB1_2677TT genotypes are associated with lower risk of pharmacoresistance than CC or GG genotypes in epileptic adults but with a higher risk in children.
DescriptionTrabajo presentado al 9th Congress of the European Association for Clinical Pharmacology and Therepeutics celebrado en edimburgo del 12 al 15 de julio de 2009.
Appears in Collections:(IBBTEC) Comunicaciones congresos
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