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Título: | Generalized deficiency of 3,5,3'-triiodo-L-thyronine (T3) in tissues from rats on a low iodine intake, despite normal circulating T3 levels |
Autor: | Escobar del Rey, Francisco; Ruiz de Oña, Carmen; Bernal, Juan CSIC ORCID; Obregón, María Jesús CSIC ORCID ; Morreale de Escobar, Gabriella CSIC | Fecha de publicación: | 1989 | Editor: | BioScientífica | Citación: | European Journal of Endocrinology 120(4): 490-498 (1989) | Resumen: | Rats fed a low iodine diet have decreased total and nuclear T3 concentrations in the liver and brain, as compared with rats supplemented with iodine, possibly because of the very low plasma and tissue T4 pools in low-iodine diet rats, leading to decreased intracellular generation of T3 in those tissues. If so, T3 levels should not decrease in heart and skeletal muscle, as plasma T3 is normal in low-iodine diet rats and these two tissues derive their intracellular T3 directly from plasma T3. We have studied this point in male rats fed a low-iodine diet, a low-iodine diet + iodine, and the stock diet. As in previous studies, low-iodine rats had very low plasma T4 and high plasma TSH levels, plasma T3 levels being normal. Liver T3 decreased, and so did the brain T3 levels despite a compensatory increase in type II 5' iodothyronine deiodinase activity. Contrary to expectations, T3 concentrations were lower in the heart and skeletal muscle of low-iodine diet rats. Attempts to clarify the possible mechanism(s) involved have been unsuccessful so far. The present results show that, despite normal plasma T3, a deficiency of T3 occurs in more tissues of rats on a low iodine intake than previously assumed. If the present results are pertinent to inhabitants from areas with severe iodine deficiency, it would appear that they might suffer from a generalized tissue T3 deficiency (and hypothyroidism?) ,even if overt clinical signs are not usually present. | URI: | http://hdl.handle.net/10261/78774 | DOI: | 10.1530/acta.0.1200490 | Identificadores: | doi: 10.1530/acta.0.1200490 issn: 0804-4643 e-issn: 1479-683X |
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