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Título

Acute damage to the posterior limb of the internal capsule on diffusion tensor tractography as an early imaging predictor of motor outcome after stroke

AutorPuig, Josep G.; Soria, Guadalupe CSIC ORCID
Fecha de publicación2011
EditorAmerican Society of Neuroradiology
CitaciónAmerican Journal of Neuroradiology 32(5): 857-863 (2011)
Resumen[Background and Purpose]: Early prediction of motor outcome is of interest in stroke management. We aimed to determine whether lesion location at DTT is predictive of motor outcome after acute stroke and whether this information improves the predictive accuracy of the clinical scores. [Materials and Methods]: We evaluated 60 consecutive patients within 12 hours of middle cerebral artery stroke onset. We used DTT to evaluate CST involvement in the motor cortex and premotor cortex, centrum semiovale, corona radiata, and PLIC and in combinations of these regions at admission, at day 3, and at day 30. Severity of limb weakness was assessed by using the motor subindex scores of the National Institutes of Health Stroke Scale (5a, 5b, 6a, 6b). We calculated volumes of infarct and fractional anisotropy values in the CST of the pons. [Results]: Acute damage to the PLIC was the best predictor associated with poor motor outcome, axonal damage, and clinical severity at admission (P < .001). There was no significant correlation between acute infarct volume and motor outcome at day 90 (P = .176, r = 0.485). The sensitivity, specificity, and positive and negative predictive values of acute CST involvement at the level of the PLIC for motor outcome at day 90 were 73.7%, 100%, 100%, and 89.1%, respectively. In the acute stage, DTT predicted motor outcome at day 90 better than the clinical scores (R 2 = 75.50, F = 80.09, P < .001). [Conclusions]: In the acute setting, DTT is promising for stroke mapping to predict motor outcome. Acute CST damage at the level of the PLIC is a significant predictor of unfavorable motor outcome. Copyright © 2011 by the American Society of Neuroradiology.
URIhttp://hdl.handle.net/10261/78495
DOI10.3174/ajnr.A2400
Identificadoresdoi: 10.3174/ajnr.A2400
issn: 0195-6108
e-issn: 1936-959X
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