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Título: | Efficient synthesis and anti-enteroviral activity of 9-arylpurines |
Autor: | Aguado, Leire CSIC; Canela, María-Dolores CSIC; Thibaut, Hendrik Jan; Priego, Eva María CSIC ORCID; Camarasa Rius, María José CSIC ORCID; Leyssen, Pieter; Neyts, Johan; Peréz-Pérez, María-Jesús CSIC ORCID | Palabras clave: | Purines Microwave-assisted synthesis Oxazolidinone Enterovirus Coxsackie virus B3 |
Fecha de publicación: | 2012 | Editor: | Elsevier | Citación: | European Journal of Medicinal Chemistry 49 : 279–288 (2012) | Resumen: | To further explore the anti-enteroviral activity of 9-aryl-6-chloropurines, three different series of compounds with a dialkylamino, (alkyl)amido, or oxazolidinone substituent at the aryl ring have been synthesized, in most cases with the aid of microwave-assisted synthesis. The resulting compounds efficiently inhibit Coxsackie virus type B3 (CVB3) replication with EC50 values varying from 3 to 15 mM, and with no significant toxicity in Vero cells. The most potent compounds also selectively inhibit the replication of other enteroviruses including Coxsackie virus B4 and Echo virus 11. The cross-resistance studies performed with different 9-aryl-6-chloropurines indicate that they all belong to the same pharmacological family and differ from other CVB3 drugs such as enviroxime. | Versión del editor: | http://dx.doi.org/10.1016/j.ejmech.2012.01.022, | URI: | http://hdl.handle.net/10261/78186 | DOI: | 10.1016/j.ejmech.2012.01.022 | ISSN: | 0223-5234 |
Aparece en las colecciones: | (IQM) Artículos |
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