Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/78010
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The new truncated somatostatin receptor variant sst5TMD4 is associated to poor prognosis in breast cancer and increases malignancy in MCF-7 cells |
Autor: | Durán-Prado, Mario; Hergueta-Redondo, Marta CSIC; Palacios Calvo, José CSIC ORCID; Moreno-Bueno, Gema CSIC ORCID; Luque, Raúl M.; Castaño, Justo P. | Fecha de publicación: | 2012 | Editor: | Nature Publishing Group | Citación: | Oncogene 31(16): 2049-2061 (2012) | Resumen: | Somatostatin receptors (sst1-5) are present in different types of tumors, where they inhibit key cellular processes such as proliferation and invasion. Although ssts are densely expressed in breast cancer, especially sst2, their role and therapeutic potential remain uncertain. Recently, we identified a new truncated sst5 variant, sst5TMD4, which is related to the abnormal response of certain pituitary tumors to treatment with somatostatin analogs. Here, we investigated the possible role of sst5TMD4 in breast cancer. This study revealed that sst5TMD4 is absent in normal mammary gland, but is abundant in a subset of poorly differentiated human breast tumors, where its expression correlated to that of sst2. Moreover, in the MCF-7 breast cancer model cell, sst5TMD4 expression increased malignancy features such as invasion and proliferation abilities (both in cell cultures and nude mice). This was likely mediated by sst5TMD4-induced increase in phosphorylated extracellular signal-regulated kinases 1 and 2 and p-Akt levels, and cyclin D3 and Arp2/3 complex expression, which also led to mesenchymal-like phenotype. Interestingly, sst5TMD4 interacts physically with sst2 and thereby alters its signaling, enabling disruption of sst2 inhibitory feedback and providing a plausible basis for our findings. These results suggest that sst5TMD4 could be involved in the pathophysiology of certain types of breast tumors. | URI: | http://hdl.handle.net/10261/78010 | DOI: | 10.1038/onc.2011.389 | Identificadores: | doi: 10.1038/onc.2011.389 issn: 0950-9232 e-issn: 1476-5594 |
Aparece en las colecciones: | (IIBM) Artículos (IBIS) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
64
checked on 11-abr-2024
WEB OF SCIENCETM
Citations
60
checked on 26-feb-2024
Page view(s)
427
checked on 22-abr-2024
Download(s)
99
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.