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http://hdl.handle.net/10261/77938
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Álvarez-Castelao, Beatriz | - |
dc.contributor.author | Castaño, José G. | - |
dc.date.accessioned | 2013-06-11T09:41:26Z | - |
dc.date.available | 2013-06-11T09:41:26Z | - |
dc.date.issued | 2011 | - |
dc.identifier | doi: 10.1007/s00018-010-0592-3 | - |
dc.identifier | issn: 1420-682X | - |
dc.identifier | e-issn: 1420-9071 | - |
dc.identifier.citation | Cellular and Molecular Life Sciences 68(15): 2643-2654 (2011) | - |
dc.identifier.uri | http://hdl.handle.net/10261/77938 | - |
dc.description.abstract | Intracellular deposits of aggregated alpha-synuclein are a hallmark of Parkinson's disease. Protein-protein interactions are critical in the regulation of cell proteostasis. Synphilin-1 interacts both in vitro and in vivo with alpha-synuclein promoting its aggregation. We report here that synphilin-1 specifically inhibits the degradation of alpha-synuclein wild-type and its missense mutants by the 20S proteasome due at least in part by the interaction of the ankyrin and coiled-coil domains of synphilin-1 (amino acids 331-555) with the N-terminal region (amino acids 1-60) of alpha-synuclein. Co-expression of synphilin-1 and alpha-synuclein wild-type in HeLa and N2A cells produces a specific increase in the half-life of alpha-synuclein, as degradation of unstable fluorescent reporters is not affected. Synphilin-1 inhibition can be relieved by co-expression of Siah-1 that targets synphilin-1 to degradation. Synphilin-1 inhibition of the proteasomal pathway of degradation of alpha-synuclein may help to understand the pathophysiological changes occurring in PD and other synucleinopathies. © Springer Basel AG 2010. | - |
dc.description.sponsorship | This work was supported by grants from SAF-2008-00766, CM SAL-0202, & CIBERNED to J. G. C. | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.rights | closedAccess | - |
dc.title | Synphilin-1 inhibits alpha-synuclein degradation by the proteasome | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1007/s00018-010-0592-3 | - |
dc.date.updated | 2013-06-11T09:41:27Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
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