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Effects of dietary ß-cyclodextrin supplemented with a culture of lactobacillus acidophilus on plasma lipid in a cholesterol enriched diet

AuthorsAlonso López, Leocadio ; Fontecha, F. Javier ; Cuesta, Paloma; Carter, S.
Issue Date2012
Citation41st Annual Food Research Conference (2012)
AbstractHeart disease is a major cause of death for humans. Nutritional studies has indicated that high concentrations of total serum cholesterol and low density lipoprotein (LDL) cholesterol correlate highly with the incidence of coronary heart disease. Several reports have showed that consumption of certain culture dairy products or culture containing dairy products supplemented with Lactobacillus acidophilus reduced concentrations of serum cholesterol. The objective of the present study was to investigate the effects of dietary ß-cyclodextrin (BCD) supplemented with a culture of lactobacillus on plasma lipid in pigs fed with a cholesterol enriched diet. For this purpose twenty four male swine weighing about 9 Kg were maintained for three weeks until they reached a weight of 17 Kg. They were ramdonly assigned to one of the following four dietary groups: no BCD (control), BCD, milk, culture. Blood samples were taken weekly from the indwelling jugular catheres just prior to the morning feeding. Inmediatly following collection the samples were then centrifuged for 20 min at 3000 x g, and the serum was stored at ¿20ºC for futher biochemical analysis. In this preliminary study it seen that the diet supplemented with BCD decreased total serum cholesterol. Suplementation of the diet with L. acidophilus decreased serum concentration of total cholesterol and LDL cholesterol, HDL and TGs remain practically constant with the diet. Possible correlation of the BCD-L. acidophilus on deconjugation of bile acids in the small intestine in controlling serum lipids. Further work is needed to evalute the effects of both L. acidophilus-BCD on serum lipid metabolim in a cholesterol enriched diet.
DescriptionTrabajo presentado al 41st Annual Food Research Conference celebrado en Cork (Irlanda) del 26 al 27 de abril de 2012.
Appears in Collections:(IPLA) Comunicaciones congresos
(CIAL) Comunicaciones congresos
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