English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/7755
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 26 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título : Energetic reserves, leptin and testosterone: a refinement of the immunocompetence handicap hypothesis
Autor : Alonso-Álvarez, Carlos ; Bertrand, S.; Sorci, Gabriele
Palabras clave : Immunocompetence handicap hypothesis
Leptin
Testosterone
Fecha de publicación : 8-mar-2007
Editor: Royal Society (Great Britain)
Citación : Biol. Lett. 3(3): 271-274 (2007)
Resumen: The immunocompetence handicap hypothesis (ICHH) assumes that testosterone (T), required for the expression of sexual traits, can also incur a cost due to its immunosuppressive properties. However, T-dependent immunosuppression could also arise as an indirect consequence of energy reallocation from the immune system to other metabolic demands. Leptin is mostly produced in lipogenic tissues and its circulating level is positively correlated with the amount of lipid reserves. Leptin also has an important role as immunoenhancer and we suggest that this hormone could play a role as a mediator of the immunosuppressive effect of testosterone. In particular, we propose that only the individuals able to maintain large lipid reserves (with high leptin levels), while sustaining high testosterone levels, might be able to develop sexual displays without an impairment of their immune defences. Here, we tested one of the assumptions underlying this extension of the ICHH: leptin administration should attenuate testosterone-induced immunosuppression. T-implanted and control male zebra finches (Taeniopygia guttata) received daily injections of leptin or phosphate buffered saline. T-implants initially depressed the phytohaemagglutinin-induced immune response. However, T-birds injected with leptin enhanced their immune response to the level of control birds. These results open a new perspective on the study of the ICHH.
Descripción : 4 pages.-- PMCID: PMC2464690.-- Printed version published on June 22, 2007.-- Electronic supplementary material is available at http://dx.doi.org/10.1098/rsbl.2007.0020 or via http://www.journals.royalsoc.ac.uk.
Versión del editor: http://dx.doi.org/10.1098/rsbl.2007.0020
URI : http://hdl.handle.net/10261/7755
DOI: 10.1098/rsbl.2007.0020
ISSN: 1744-9561
Aparece en las colecciones: (IREC) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.