Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/77538
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Pharmacological strategies against cold ischemia reperfusion injury |
Autor: | Zaouali, Mohamed A. CSIC ORCID; Padrissa-Altés, Susagna CSIC; Roselló-Catafau, Joan CSIC ORCID | Fecha de publicación: | 2010 | Editor: | Informa Healthcare | Citación: | Expert Opinion on Pharmacotherapy 11(4): 537-555 (2010) | Resumen: | Importance of the field: Good organ preservation is a determinant of graft outcome after revascularization. The necessity of increasing the quality of organ preservation, as well as of extending cold storage time, has made it necessary to consider the use of pharmacological additives. Areas covered in this review: The complex physiopathology of cold-ischemia-reperfusion (I/R) injury - and in particular cell death, mitochondrial injury and endoplasmic reticulum stress - are reviewed. Basic principles of the formulation of the different preservation solutions are discussed. What the reader will gain: Current strategies and new trends in static organ preservation using additives such as trimetazidine, polyethylene glycols, melatonin, trophic factors and endothelin antagonists in solution are presented and discussed. The benefits and mechanisms responsible for enhancing organ protection against I/R injury are also discussed. Graft preservation was substantially improved when additives were added to the preservation solutions. Take home message: Enrichment of preservation solutions by additives is clinically useful only for short periods. For longer periods of cold ischemia, the use of such additives becomes insufficient because graft function deteriorates as a result of ischemia. In such conditions, the preservation strategy should be changed by the use of machine perfusion in normothermic conditions. © 2010 Informa UK Ltd. | Versión del editor: | http://dx.doi.org/10.1517/14656560903547836 | URI: | http://hdl.handle.net/10261/77538 | DOI: | 10.1517/14656560903547836 | Identificadores: | doi: 10.1517/14656560903547836 issn: 1465-6566 e-issn: 1744-7666 |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
55
checked on 22-mar-2024
WEB OF SCIENCETM
Citations
52
checked on 23-feb-2024
Page view(s)
286
checked on 29-mar-2024
Download(s)
133
checked on 29-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.