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New insights into fatty liver preservation using Institute Georges Lopez preservation solution

AuthorsZaouali, Mohamed A. ; Mosbah, Ismail Ben ; Peralta, Carmen; Roselló-Catafau, Joan
Issue Date2010
CitationTransplantation Proceedings 42(1): 159-161 (2010)
AbstractInstitute Georges Lopez preservation solution (IGL-1) has been demonstrated to be useful for fatty liver preservation. The mechanisms responsible for this effective graft protection against ischemia-reperfusion injury are pivotal actions on generation of nitric oxide a diffusible molecule with vasodilator properties, that facilitates the up-regulation of other well-known cytoprotective genes, such as hypoxia-inducible factor-1 alpha (HIF-1α) and heme-oxygenase 1 (HO-1). During normoxic reperfusion, the presence of nitric oxide permits HIF-1α accumulation to inhibit prolyl-hydoxylases, thus promoting an additional overexpression of the HO-1 in steatotic and nonsteatotic graft livers preserved in IGL-1. © 2010.
DescriptionEl pdf es la versión post-print.-- et al.
Publisher version (URL)http://dx.doi.org/10.1016/j.transproceed.2009.12.035
Identifiersdoi: 10.1016/j.transproceed.2009.12.035
issn: 0041-1345
Appears in Collections:(IIBB) Artículos
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