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dc.contributor.author | Cuadrado-Berrocal, Irene | - |
dc.contributor.author | Fernández-Velasco, María | - |
dc.contributor.author | Boscá, Lisardo | - |
dc.contributor.author | Heras, Beatriz de las | - |
dc.date.accessioned | 2013-05-31T10:19:04Z | - |
dc.date.available | 2013-05-31T10:19:04Z | - |
dc.date.issued | 2011 | - |
dc.identifier | doi: 10.1038/cddis.2011.113 | - |
dc.identifier | issn: 2041-4889 | - |
dc.identifier.citation | Cell Death and Disease 2: e229 (2011) | - |
dc.identifier.uri | http://hdl.handle.net/10261/77265 | - |
dc.description.abstract | Several labdane diterpenes exert anti-inflammatory and cytoprotective actions; therefore, we have investigated whether these molecules protect cardiomyocytes in an anoxia/reperfusion (A/R) model, establishing the molecular mechanisms involved in the process. The cardioprotective activity of three diterpenes (T1, T2 and T3) was studied in the H9c2 cell line and in isolated rat cardiomyocyte subjected to A/R injury. In both cases, treatment with diterpenes T1 and T2 protected from A/R-induced apoptosis, as deduced by a decrease in the percentage of apoptotic and caspase-3 active positive cells, a decrease in the Bcl-2/Bax ratio and an increase in the expression of antiapoptotic proteins. Analysis of cell survival signaling pathways showed that diterpenes T1 and T2 added after A/R increased phospho-AKT and phospho-ERK 1/2 levels. These cardioprotective effects were lost when AKT activity was pharmacologically inhibited. Moreover, the labdane-induced cardioprotection involves activation of AMPK, suggesting a role for energy homeostasis in their mechanism of action. Labdane diterpenes (T1 and T2) also exerted cardioprotective effects against A/R-induced injury in isolated cardiomyocytes and the mechanisms involved activation of specific survival signals (PI3K/AKT pathways, ERK1/2 and AMPK) and inhibition of apoptosis. | - |
dc.description.sponsorship | This work was supported by grants BFU2011-24760 and PIB2010BZ-00540 from MICINN; red temática de investigación en enfermedades cardiovasculares (RECAVA, RD06/0014/0006), the Instituto de Salud Carlos III (ISCIII), MICINN and European Regional Development Fund (ERDF) ‘Una manera de hacer Europa’ and CIBERehd founded by Instituto de Salud Carlos III. | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | openAccess | - |
dc.title | Labdane diterpenes protect against anoxia/reperfusion injury in cardiomyocytes: involvement of AKT activation | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1038/cddis.2011.113 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1038/cddis.2011.113 | - |
dc.date.updated | 2013-05-31T10:19:04Z | - |
dc.description.version | Peer Reviewed | - |
dc.identifier.pmid | 22071634 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.openairetype | artículo | - |
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Labdane diterpenes.pdf | 498,87 kB | Adobe PDF | Visualizar/Abrir |
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