English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/77121
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Accelerated exon evolution within primate segmental duplications

AuthorsLorente-Galdós, Belén ; Bleyhl, Jonathan; Santpere, Gabriel ; Vives, Laura; Ramírez, Óscar ; Hernandez, Jessica; Anglada, Roger; Cooper, Gregory M; Navarro, Arcadi ; Eichler, Evan E.; Marqués-Bonet, Tomàs
Issue Date29-Jan-2013
PublisherBioMed Central
CitationGenome Biology 14(1): R9 (2013)
Abstract[Background] The identification of signatures of natural selection has long been used as an approach to understanding the unique features of any given species. Genes within segmental duplications are overlooked in most studies of selection due to the limitations of draft nonhuman genome assemblies and to the methodological reliance on accurate gene trees, which are difficult to obtain for duplicated genes.
[Results] In this work, we detected exons with an accumulation of high-quality nucleotide differences between the human assembly and shotgun sequencing reads from single human and macaque individuals. Comparing the observed rates of nucleotide differences between coding exons and their flanking intronic sequences with a likelihood-ratio test, we identified 74 exons with evidence for rapid coding sequence evolution during the evolution of humans and Old World monkeys. Fifty-five percent of rapidly evolving exons were either partially or totally duplicated, which is a significant enrichment of the 6% rate observed across all human coding exons.
[Conclusions] Our results provide a more comprehensive view of the action of selection upon segmental duplications, which are the most complex regions of our genomes. In light of these findings, we suggest that segmental duplications could be subjected to rapid evolution more frequently than previously thought.
DescriptionThis is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher version (URL)http://dx.doi.org/10.1186/gb-2013-14-1-r9
URIhttp://hdl.handle.net/10261/77121
DOI10.1186/gb-2013-14-1-r9
ISSN1465-6906
Appears in Collections:(IBE) Artículos
Files in This Item:
File Description SizeFormat 
gb-2013-14-1-r9.xml135,7 kBXMLView/Open
GB-2013-14-1-R9-S2.XLS69,5 kBMicrosoft ExcelView/Open
GB-2013-14-1-R9-S5.PDF1,3 MBAdobe PDFThumbnail
View/Open
gb-2013-14-1-r9.pdf2,28 MBAdobe PDFThumbnail
View/Open
GB-2013-14-1-R9-S1.PDF1,67 MBAdobe PDFThumbnail
View/Open
GB-2013-14-1-R9-S3.PDF8,51 MBAdobe PDFThumbnail
View/Open
GB-2013-14-1-R9-S6.PDF194,11 kBAdobe PDFThumbnail
View/Open
GB-2013-14-1-R9-S4.PDF16,22 MBAdobe PDFThumbnail
View/Open
Show full item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.