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Title

Emerging role of neuregulin as a modulator of muscle metabolism

AuthorsGumà, Anna; Martínez-Redondo, Vicente; López-Soldado, Iliana; Cantó, Carles; Zorzano, Antonio
Issue Date2010
PublisherAmerican Physiological Society
CitationAmerican Journal of Physiology - Endocrinology and Metabolism 298(4): E742-E750 (2010)
AbstractNeuregulin was described initially as a neurotrophic factor involved in the formation of the neuromuscular junction in skeletal muscle. However, in recent years, neuregulin has been reported to be a myokine that exerts relevant effects on myogenesis and the regulation of muscle metabolism. In this new context, the rapid and chronic metabolic effects of neuregulin appear to be related to muscle contraction. Indeed, the effects of neuregulin resemble those of exercise, which are accompanied by an improvement in insulin sensitivity. In this review, we challenge the classical role assigned to neuregulin in muscle and propound the emerging concept of its involvement in the regulation of energetic metabolism and insulin responsiveness. Copyright © 2010 the American Physiological Society.
URIhttp://hdl.handle.net/10261/76938
DOI10.1152/ajpendo.00541.2009
Identifiersdoi: 10.1152/ajpendo.00541.2009
issn: 0193-1849
e-issn: 1522-1555
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