Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/76899
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Gorina, Roser | - |
dc.contributor.author | Planas, Anna M. | - |
dc.contributor.author | Vergés, José A. | - |
dc.contributor.author | López, Manuela G. | - |
dc.date.accessioned | 2013-05-28T07:18:11Z | - |
dc.date.available | 2013-05-28T07:18:11Z | - |
dc.date.issued | 2010 | - |
dc.identifier | doi: 10.1016/j.neuroscience.2010.02.069 | - |
dc.identifier | issn: 0306-4522 | - |
dc.identifier.citation | Neuroscience 167(3): 872-879 (2010) | - |
dc.identifier.uri | http://hdl.handle.net/10261/76899 | - |
dc.description | et al. | - |
dc.description.abstract | Chondroitin sulfate (CS) is a glucosaminoglycan (GAG) currently used for the treatment of osteoarthritis because of its antiinflammatory and antiapoptotic actions. Recent evidence has revealed that those peripheral effects of CS may also have therapeutic interest in diseases of the CNS. Since neuroinflammation has been implicated in different neuronal pathologies, this study was planned to investigate how CS could modulate the inflammatory response in the CNS by using rat astrocyte cultures stimulated with lipopolysaccharide (LPS). We have evaluated different proteins implicated in the nuclear factor kappa B (NFK{green}) and Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathways employing RT-PCR, western blot and immunofluorescence techniques. At 10 μM, CS prevented translocation of p65 to the nucleus, reduced tumour necrosis factor alpha (TNF-α) mRNA and mitigated cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) induction by LPS. However, it did not modify LPS-induced IP-10 and SOCS-1 mRNA, proteins that participate in the JAK/STAT pathway. The results of this study indicate that CS can potentially reduce neuroinflammation by inhibition of NFK{green}B. Therefore endogenous GAGs could afford neuroimmunomodulatory actions under neurotoxic conditions. © 2010 IBRO. | - |
dc.description.sponsorship | This work was supported by “Cátedra Bioibérica/UAM de Inflamación Crónica y Citoprotección”(CABICYC) Spain and, in part by the Spanish Ministry of Science and Innovation Ref. SAF2009-12150 to MGL, SAF2008-04515-C02-01 to AMP, the Spanish Ministry of Health (Instituto de Salud Carlos III) RETICS-RD06/0026, Comunidad Autónoma de Madrid SAL2006/0275, Fundación CIEN, IS Carlos III, MICINN, N° PI016/09 and Agencia Lain Entralgo, CN N° NDE07/09, Comunidad de Madrid, Spain to AGG. | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.rights | closedAccess | - |
dc.title | Chondroitin sulfate inhibits lipopolysaccharide-induced inflammation in rat astrocytes by preventing nuclear factor kappa B activation | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.neuroscience.2010.02.069 | - |
dc.date.updated | 2013-05-28T07:18:11Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
35
checked on 09-abr-2024
WEB OF SCIENCETM
Citations
30
checked on 28-feb-2024
Page view(s)
322
checked on 23-abr-2024
Download(s)
126
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.