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Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement

AuthorsCastanys-Muñoz, E.; Pérez-Victoria, J. M. ; Gamarro, Francisco; Castanys, Santiago
Issue Date2008
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 52: 3573- 3579 (2008)
AbstractLeishmaniasis treatment is hampered by the increased appearance of treatment failure. ATP-binding cassette (ABC) transporters are usually involved in drug resistance both in tumor cells and in microorganisms. Here we report the characterization of an ABCG-like transporter, LiABCG6, localized mainly at the plasma membrane in Leishmania protozoan parasites. When overexpressed, this half-transporter confers significant resistance to the leishmanicidal agents miltefosine and sitamaquine. This resistance phenotype is mediated by a reduction in intracellular drug accumulation. LiABCG6 also reduces the accumulation of short-chain fluorescent phospholipid analogues of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine. As a whole, these results suggest that LiABCG6 could be implicated in phospholipid trafficking and drug resistance. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Identifiersdoi: 10.1128/AAC.00587-08
issn: 0066-4804
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