English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/76795
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Early development of the vertebrate inner ear

AuthorsMagariños, Marta ; Contreras, Julio ; Rodríguez Aburto, María ; Varela-Nieto, Isabel
Issue Date2012
PublisherWiley-Blackwell
CitationAnatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 295(11): 1775-1790 (2012)
AbstractThis is a review of the biological processes and the main signaling pathways required to generate the different otic cell types, with particular emphasis on the actions of insulin-like growth factor I. The sensory organs responsible of hearing and balance have a common embryonic origin in the otic placode. Lineages of neural, sensory, and support cells are generated from common otic neuroepithelial progenitors. The sequential generation of the cell types that will form the adult inner ear requires the coordination of cell proliferation with cell differentiation programs, the strict regulation of cell survival, and the metabolic homeostasis of otic precursors. A network of intracellular signals operates to coordinate the transcriptional response to the extracellular input. Understanding the molecular clues that direct otic development is fundamental for the design of novel treatments for the protection and repair of hearing loss and balance disorders. © 2012 Wiley Periodicals, Inc.
URIhttp://hdl.handle.net/10261/76795
DOI10.1002/ar.22575
Identifiersdoi: 10.1002/ar.22575
issn: 1932-8486
e-issn: 1932-8494
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.