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P68 RNA helicase (DDX5) alters activity of cis- and trans-acting factors of the alternative splicing of H-Ras

AuthorsCamats, Maria; Guil, Sonia ; Kokolo, Mariette; Bach-Elias, Montse
Issue DateAug-2008
PublisherPublic Library of Science
CitationPLoS ONE 3(8): e2926 (2008)
Abstract[Background]: H-Ras pre-mRNA undergoes an alternative splicing process to render two H-Ras, due to either the exclusion or inclusion of the alternative intron D exon (IDX), known to reduce IDX inclusion. [Principal Findings]: Here we show that p68 unwinds the stem-loop IDX-rasISS1 structure to IDX-rasISS1. We also found that p68 alters the dynamic localization of SC35, a splicing The knockdown of hnRNP A1, FUS/TLS and hnRNP H resulted in upregulation of the SC35-binding protein, SFRS2IP. Finally, FUS/TLS was observed to upregulate p19 expression and in vivo RNAi-mediated depletion of hnRNP H decreased p19 H-Ras abundance. [Significance]: Taken together, p68 is shown to be an essential player in the regulation transduction signal pathway tied to cell proliferation and many cancer processes.
DescriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License.
Publisher version (URL)http://dx.doi.org/10.1371/journal.pone.0002926
Appears in Collections:(IIBB) Artículos
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