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Título: | Calmodulin regulates the translocation of Grb7 into the nucleus |
Autor: | García-Palmero, Irene CSIC; Villalobo, Antonio CSIC ORCID | Fecha de publicación: | 2012 | Editor: | Elsevier | Citación: | FEBS Letters 586(10): 1536-1539 (2012) | Resumen: | We describe in this report the presence of a nuclear localization signal (NLS) overlapping the calmodulin-binding domain (CaM-BD) of the growth factor receptor bound protein 7 (Grb7). We show that deletion of the CaM-BD of Grb7 prevents its nuclear localization, and that its Src homology 2 (SH2) domain might participate as well in the translocation process. Also, treating cells with the CaM antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) enhances the presence of Grb7 in the nucleus. We propose that CaM inhibits the translocation of Grb7 to the nucleus after binding to its CaM-BD and therefore occluding its overlapping NLS. | URI: | http://hdl.handle.net/10261/76504 | DOI: | 10.1016/j.febslet.2012.04.017 | Identificadores: | doi: 10.1016/j.febslet.2012.04.017 issn: 0014-5793 e-issn: 1873-3468 |
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