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Title

Calmodulin regulates the translocation of Grb7 into the nucleus

AuthorsGarcía-Palmero, Irene ; Villalobo, Antonio
Issue Date2012
PublisherElsevier
CitationFEBS Letters 586(10): 1536-1539 (2012)
AbstractWe describe in this report the presence of a nuclear localization signal (NLS) overlapping the calmodulin-binding domain (CaM-BD) of the growth factor receptor bound protein 7 (Grb7). We show that deletion of the CaM-BD of Grb7 prevents its nuclear localization, and that its Src homology 2 (SH2) domain might participate as well in the translocation process. Also, treating cells with the CaM antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) enhances the presence of Grb7 in the nucleus. We propose that CaM inhibits the translocation of Grb7 to the nucleus after binding to its CaM-BD and therefore occluding its overlapping NLS.
URIhttp://hdl.handle.net/10261/76504
DOI10.1016/j.febslet.2012.04.017
Identifiersdoi: 10.1016/j.febslet.2012.04.017
issn: 0014-5793
e-issn: 1873-3468
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