English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/76494
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats

AuthorsCauli, Omar; López-Larrubia, Pilar ; Rodrigo, Regina; Agustí, Ana; Boix, J.; Nieto-Charques, Laura ; Cerdán, Sebastián ; Felipo, Vicente
Issue Date2011
CitationGastroenterology 140(2): 638-645 (2011)
Abstract[Background and Aims]: Patients with acute liver failure (ALF) often die of intracranial pressure (IP) and cerebral herniation. Main contributors to increased IP are ammonia, glutamine, edema, and blood flow. The sequence of events and underlying mechanisms, as well as the temporal pattern, regional distribution, and contribution of each parameter to the progression of neurologic deterioration and IP, are unclear. We studied rats with ALF to follow the progression of changes in ammonia, glutamine, grade and type (vasogenic or cytotoxic) of edema, blood-brain barrier permeability, cerebral blood flow, and IP. We assessed whether the changes in these parameters were similar between frontal cortex and cerebellum and evaluated the presence, type, and progression of edema in 12 brain areas. [Methods]: ALF was induced by injection of galactosamine. The grade and type of edema was assessed by measuring the apparent diffusion coefficient by magnetic resonance imaging. Cerebral blood flow was measured by magnetic resonance and blood-brain barrier permeability by Evans bluealbumin extravasation. [Results]: Increased IP arises from an early increase of bloodbrain barrier permeability in certain areas (including cerebellum but not frontal cortex) followed by vasogenic edema. Ammonia and glutamine then increase progressively, leading to cytotoxic edema in many areas. Alterations in lactate and cerebral blood flow are later events that further increase IP. [Conclusions]: Different mechanisms in specific regions of the brain contribute, with different temporal patterns, to the progression of cerebral alterations and IP in ALF. © 2011 AGA Institute.
Identifiersdoi: 10.1053/j.gastro.2010.10.043
issn: 0016-5085
e-issn: 1528-0012
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.