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Inhibitors of sip receptors for the treatment of calcific aortic stenosis

Other TitlesInhibidores de receptores de sip para el tratamiento de la estenosis aórtica calcificada
AuthorsGarcía-Rodríguez, Carmen ; Sánchez Crespo, Mariano; San Román, José Alberto
Issue Date20-Sep-2012
CitationWO2012123613 A1
Abstract[EN] The invention relates to the use of at least one inhibitor of sphingosine-l-phosphate (SI P) receptors, preferably of receptors SI PI, SI P3, SI P4 or SI P2, for the preparation of a drug for preventing and/or treating calcified aortic stenosis. More preferably, the inhibitor is an antagonist or an interfering RNA.
[ES] La presente invención se refiere al uso de al menos un inhibidor de los receptores de esfmgosina-l -fosfato (SI P), preferiblemente de los receptores SI PI, SI P3, SI P4 o SI P2, para la elaboración de un medicamento para la prevención y/o el tratamiento de la estenosis aórtica calcificada. Más preferiblemente el inhibidor es un antagonista o un ARN de interferencia.
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