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Title

The rpap1 gene product is expressed in multiple stem cell niches, regulates stem cell differentiation and represses ips reprogramming

AuthorsSerrano, Manuel; Liynch Cian, Joseph; Rojo, Enrique; Sanmartín, Maite; Sánchez Serrano, José J.
Issue Date20-Dec-2012
CitationWO2012171744 A1
AbstractThe RPAP1 gene product is expressed in multiple stem cell niches, regulates stem cell differentiation and represses iPS reprogramming. Thus, it can be used as a marker of pluripotent or multipotent cells, such as embryonic, or adult stem cells and induced pluripotent cells. Its suppression or inhibition can be used to increase the efficiency of the transformation of more differentiated cells, such as fibroblast, into induced pluripotent cells, as well as to increase the number of pluripotent cells in cultures of stem cells.
URIhttp://hdl.handle.net/10261/76303
Appears in Collections:(CNB) Patentes
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