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Influence of mutations of proteinase activated receptors F2R/PAR1 and F2RL1/PAR2 on inflammatory bowel disease | Influencia de las mutaciones de los receptores activados por proteinasa F2R/PAR1 y F2RL1/PAR2 en la enfermedad inflamatoria intestinal

AuthorsMartín, M. C.; Oliver, Francisco Javier; Luis Mendoza, J.; Fernández-Arquero, M.; Martín, J.; Urcelay, Elena
Issue Date2008
CitationMedicina Clinica 131: 609- 611 (2008)
AbstractBackground and objective: Inflammatory bowel disease (IBD) is a polygenic complex trait. The expression and presence in biopsiae from IBD patients points to a putative role of these genes in genetic susceptibility to IBD. This is the first association study on these genes in relation with IBD. Patients and method: Two polymorphisms were analyzed within F2R/PAR1 and another one mapping to F2RL1/PAR2 in 778 healthy controls and 943 IBD cases (Crohn's disease and ulcerative colitis patients from 2 cohorts from Madrid and Granada). Results: No significant differences in the distribution of the PARs' polymorphisms were found. Conclusions: There is no evidence of association of the analyzed polymorphisms with IBD risk. © 2008 Elsevier España S.L. All rights reserved.
Identifiersdoi: 10.1157/13127918
issn: 0025-7753
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