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Increased association of CD38 with lipid rafts in T cells from patients with systemic lupus erythematosus and in activated normal T cells

AuthorsPavón, Esther J.; Muñoz, P.; Navarro, M. D. C.; Raya-Álvarez, E.; Callejas-Rubio, J. L.; Navarro-Pelayo, F.; Ortego-Centeno, N.; Sancho, Jaime CSIC ORCID ; Zubiaur, Mercedes CSIC ORCID
Issue Date2006
PublisherPergamon Press
CitationMolecular Immunology 43: 1029- 1039 (2006)
AbstractIn this study we have determined whether there is a relationship between CD38 expression on T cells, its distribution in different membrane microdomains, and T cell activation in SLE patients. The data show that CD38 expression is augmented in ex vivo CD3+, CD4+, CD8+, and CD25+ SLE T cells, which correlates with its increased insolubility in Brij 98 detergent, and its translocation into lipid rafts. Moreover, SLE T cells show an altered CD4:CD8 ratio, which is due to a decreased proportion of CD4+ T cells and a concomitant increase in the proportion of CD8 + T cells. These data are consistent with the increased CD38 expression and lipid raft formation, and the significant reduction in the CD4:CD8 ratio observed in mitogen-stimulated normal T cells as compared with that in ex vivo untouched normal T cells. Increased expression of CD38 in floating rafts from SLE T cells, or from activated normal T cells may modulate TCR signaling by providing or sequestering signaling molecules to the engaged TCR. © 2005 Elsevier Ltd. All rights reserved.
Identifiersdoi: 10.1016/j.molimm.2005.05.002
issn: 0161-5890
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