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G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance

AuthorsMayor Menéndez, Federico ; Lucas, Elisa ; Jurado-Pueyo, María; García-Guerra, Lucía; Nieto-Vázquez, Iria; Vila-Bedmar, Rocío ; Fernández-Veledo, Sonia; Murga, Cristina
KeywordsG protein-coupled receptors
Issue Date2011
PublisherInforma Healthcare
CitationArchives of Physiology and Biochemistry 117(3):125-30 (2011)
AbstractG protein-coupled receptor kinase 2 (GRK2) is emerging as a key, integrative node in many signalling pathways. Besides its canonical role in the modulation of the signalling mediated by many G protein-coupled receptors (GPCR), this protein can display a very complex network of functional interactions with a variety of signal transduction partners, in a stimulus, cell type, or context-specific way. We review herein recent data showing that GRK2 can regulate insulin-triggered transduction cascades at different levels and that this protein plays a relevant role in insulin resistance and obesity in vivo, what uncovers GRK2 as a potential therapeutic target in the treatment of these disorders.
Publisher version (URL)http://dx.doi.org/10.3109/13813455.2011.584693
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