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Second generation of fucose-based DC-SIGN ligands: Affinity improvement and specificity versus Langerin

AuthorsAndreini, Manuel; Doknic, Daniela; Sutkeviciute, Ieva; Reina, José J. ; Duan, Janxin; Chabrol, Eric; Thépaut, Michel; Moroni, Elisabetta; Doro, Fabio; Belvisi, Laura; Weiser, Jöerg; Rojo, Javier ; Fieschi, Franck; Bernardi, Anna
Issue Date2011
PublisherRoyal Society of Chemistry (UK)
CitationOrganic and Biomolecular Chemistry 9: 5778- 5786 (2011)
AbstractDC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (LeX). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection. © 2011 The Royal Society of Chemistry.
Identifiersdoi: 10.1039/c1ob05573a
issn: 1477-0520
Appears in Collections:(IIQ) Artículos
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