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http://hdl.handle.net/10261/74976
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | López García, Daniel | es_ES |
dc.contributor.author | Jiménez, Mercedes | es_ES |
dc.contributor.author | García-Calvo, Margarita | es_ES |
dc.contributor.author | Val, Margarita del | es_ES |
dc.date.accessioned | 2013-04-23T18:56:29Z | - |
dc.date.available | 2013-04-23T18:56:29Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Journal of Biological Chemistry 286(19):16910-3 (2011) | es_ES |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10261/74976 | - |
dc.description.abstract | The generation of peptides presented by MHC class I molecules requires the proteolytic activity of the proteasome and/or other peptidases. The processing of a short vaccinia virus-encoded antigen can take place by a proteasome-independent pathway involving initiator caspase-5 and -10, which generate antigenic peptides recognized by CD8(+) T lymphocytes. In the present study, comparing single versus double enzyme digestions by mass spectrometry analysis, both qualitative and quantitative differences in the products obtained were identified. These in vitro data suggest that each enzyme can use the degradation products of the other as substrate for new cleavages, indicating concerted endoproteolytic activity of caspase-5 and -10. | es_ES |
dc.description.sponsorship | This work was supported by grants provided by the European Union, Ministerio de Ciencia e Innovación, Comunidad de Madrid, and Instituto de Salud Carlos III to M. D. V., and by Programa Ramón y Cajal and FIPSE Foundation to D. L. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Biochemistry and Molecular Biology | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Antigen processing | es_ES |
dc.subject | Caspases | es_ES |
dc.subject | Mass spectrometry (MS) | es_ES |
dc.subject | MHC | es_ES |
dc.subject | Protease | es_ES |
dc.subject | Virus | es_ES |
dc.title | Concerted antigen processing of a short viral antigen by human caspases 5 and 10 | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1074/jbc.M111.234658 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1074/jbc.M111.234658 | es_ES |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Fundación para la Investigación y la Prevención del Sida en España | - |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007671 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.identifier.pmid | 21454616 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
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