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Title

Concerted antigen processing of a short viral antigen by human caspases 5 and 10

AuthorsLópez, Daniel CSIC ORCID ; Jiménez, Mercedes CSIC ORCID ; García-Calvo, Margarita; Val, Margarita del CSIC ORCID
KeywordsAntigen processing
Caspases
Mass spectrometry (MS)
MHC
Protease
Virus
Issue Date2011
PublisherAmerican Society for Biochemistry and Molecular Biology
CitationJournal of Biological Chemistry 286(19):16910-3 (2011)
AbstractThe generation of peptides presented by MHC class I molecules requires the proteolytic activity of the proteasome and/or other peptidases. The processing of a short vaccinia virus-encoded antigen can take place by a proteasome-independent pathway involving initiator caspase-5 and -10, which generate antigenic peptides recognized by CD8(+) T lymphocytes. In the present study, comparing single versus double enzyme digestions by mass spectrometry analysis, both qualitative and quantitative differences in the products obtained were identified. These in vitro data suggest that each enzyme can use the degradation products of the other as substrate for new cleavages, indicating concerted endoproteolytic activity of caspase-5 and -10.
Publisher version (URL)http://dx.doi.org/10.1074/jbc.M111.234658
URIhttp://hdl.handle.net/10261/74976
DOI10.1074/jbc.M111.234658
ISSN0021-9258
Appears in Collections:(CBM) Artículos

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