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Title

Functional interplay between tetraspanins and proteases

AuthorsYáñez-Mó, María; Gutiérrez-López, María Dolores CSIC; Cabañas, Carlos CSIC ORCID
KeywordsTetraspanins
MMP
ADAMS
a-secretases
Shedding
RIP
Issue Date2011
PublisherSpringer
CitationCellular and Molecular Life Sciences 68:3323–3335 (2011)
AbstractSeveral recent publications have described examples of physical and functional interations between tetraspanins and specific membrane proteases belonging to the TM-MMP and a-(ADAMs) and c-secretases families. Collectively, these examples constitute an emerging body of evidence supporting the notion that tetraspanin-enriched microdomains (TEMs) represent functional platforms for the regulation of key cellular processes including the release of surface protein ectodomains (‘‘shedding’’), regulated intramembrane proteolysis (‘‘RIPing’’) and matrix degradation and assembly. These cellular processes in turn play a crucial role in an array of physiological and pathological phenomena. Thus, TEMs may represent new therapeutical targets that may simultaneously affect the proteolytic activity of different enzymes and their substrates. Agonistic or antagonistic antibodies and blocking soluble peptides corresponding to tetraspanin functional regions may offer new opportunities in the treatment of pathologies such as chronic inflammation, cancer, or Alzheimer’s disease. In this review article, we will discuss all these aspects of functional regulation of protease activities by tetraspanins.
Publisher version (URL)http://dx.doi.org/10.1007/s00018-011-0746-y
URIhttp://hdl.handle.net/10261/74966
DOI10.1007/s00018-011-0746-y
ISSN1420-682X
Appears in Collections:(CBM) Artículos




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