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Título

Fluid-dynamical basis of the embryonic development of left right asymmetry in vertebrates

Autor Cartwright, Julyan H. E.; Piro, Oreste ; Tuval, Idan
Palabras clave Physics
Developmental biology
Fecha de publicación 11-may-2004
EditorNational Academy of Sciences (U.S.)
Citación Proceedings of the National Academy of Sciences of the USA (PNAS) 101(19): 7234-7239 (2004)
ResumenExperimental work in developmental biology has recently shown in mice that fluid flow driven by rotating cilia in the node, a structure present in the early stages of growth of vertebrate embryos, is responsible for determining the normal development of the left--right axis, with the heart on the left of the body, the liver on the right, and so on. The role of physics, in particular of fluid dynamics, in the process, is one of the important questions that remain to be answered. We show with an analysis of the fluid dynamics of the nodal flow in the developing embryo that the leftward flow that has been experimentally observed may be produced by the monocilia driving it being tilted toward the posterior. We propose a model for morphogen transport and mixing in the nodal flow, and discuss how this might initiate the development of left--right asymmetry.
Descripción 6 pages, 4 figures.-- PMCID: PMC409902.-- Open Access version available at PMC: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=409902.-- Supplementary material available: Supporting text "Modeling with rotlets" (3 pages).
Versión del editorhttp://dx.doi.org/10.1073/pnas.0402001101
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=409902
URI http://hdl.handle.net/10261/7489
DOI10.1073/pnas.0402001101
ISSN0027-8424
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