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Title

WIP Is a Negative Regulator of Neuronal Maturation and Synaptic Activity

AuthorsFranco-Villanueva, Ana; Knafo, Shira; Bañón-Rodríguez, Inmaculada CSIC; Merino-Serrais, Paula CSIC ORCID; Fernaud-Espinosa, Isabel CSIC ORCID; Garrido Jurado, Juan José CSIC ORCID ; Esteban, José A. CSIC ORCID; Wandosell, Francisco CSIC ORCID ; Antón, Inés María; Nieto, M.
KeywordsDendritic spine
Electrophysiology
Neuritogenesis
N-WASP
Synapse
Issue Date2012
PublisherOxford University Press
CitationCerebral Cortex
AbstractWiskott–Aldrich syndrome protein (WASP) –interacting protein (WIP) is an actin-binding protein involved in the regulation of actin polymerization in cells, such as fibroblasts and lymphocytes. Despite its recognized function in non-neuronal cells, the role of WIP in the central nervous system has not been examined previously. We used WIP-deficient mice to examine WIP function both in vivo and in vitro. We report here that WIP−/− hippocampal neurons exhibit enlargement of somas as well as overgrowth of neuritic and dendritic branches that are more evident in early developmental stages. Dendritic arborization and synaptogenesis, which includes generation of postsynaptic dendritic spines, are actin-dependent processes that occur in parallel at later stages. WIP deficiency also increases the amplitude and frequency of miniature excitatory postsynaptic currents, suggesting that WIP−/− neurons have more mature synapses than wild-type neurons. These findings reveal WIP as a previously unreported regulator of neuronal maturation and synaptic activity.
Publisher version (URL)http://dx.doi.org/10.1093/cercor/bhr199
URIhttp://hdl.handle.net/10261/74748
DOIhttp://dx.doi.org/10.1093/cercor/bhr199
ISSN1047-3211
Appears in Collections:(CBM) Artículos
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