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Functional magnetic nanoparticles for life sciences

AuthorsMarquina, Clara CSIC ORCID; Pérez de Luque, Alejandro CSIC ORCID; Goya, Gerardo F.; Fernández-Pacheco, Rodrigo; Asín, Laura; Fuente, Jesús M. de la; Risueño, María Carmen CSIC ORCID; Testillano, P. S. CSIC ORCID ; Ibarra, M. Ricardo CSIC ORCID
Issue Date2012
PublisherChartridge Books Oxford
CitationHot Topics in Cell Biology : 221-226 (2012)
AbstractThis contribution is focused on the increasing interest for the application of magnetic nanoparticles in life sciences. There exist a broad scientific scenario concerning how new inorganic functional nanostructured materials interact with elemental biological units, in particulars with cells. In the field of medicine new therapy and diagnosis agents are being investigated with the goals of a selective drug delivery and an early diagnosis. Although incipient and promising applications in the clinic are encouraging the new field of nanobiomedicine, this discipline still is in the infancy but the scientific interest is rapidly increasing and nowadays it is considered as the main candidate for effective treatment of cancer and neurodegenerative diseases. [1,2] Other emerging activity in this field concerns with the application of nanoparticles in plants [3,4]. One can image the great impact in agriculture, ecology and health food. There exists an overwhelming lack of information concerning the interaction of functional nanoparticles with plants, which is a topic of major interest in environment, phytosanitary and food industries. In this contribution a broad overview on the interdisciplinary investigations carried out in collaboration with several research groups is given. The reported results deal with iron nanoparticles encapsulated in a carbon matrix (Fe@C). The magnetic behavior and the biocompatibility of these nanostructures provide an excellent frame of work in order to visualize, drive, heat, change the magnetic neighborhood of cells, tissues and organs. The magnetic behavior of the nanoparticles has a strong influence on the local internal fields of the tissues modifying the protons resonance of H atom in water; this is relevant for enhancing the MRI contrast. Location of magnetic nanoparticles can be favored by steady magnetic fields and local heating (magnetic hyperthermia) by application of radiofrequency electromagnetic fields. Cell separation or labeling is other important scenario for application of nanoparticles in cell biology. Internalization of magnetic nanoparticles favors gene therapy by application of magnetic fields. The scope of this talk is to establish a parallelism between application of nanotechnology in animal and plant kingdoms, a clear example is the selective drug or chemical release with clear application in therapy or in agriculture.
DescriptionResumen del trabajo presentado al XIV Congreso de la Sociedad Española de Biología Molecular celebrado en Malaga del 12 al 15 de diciembre de 2011 y posteriormente al INTERMAG 2012 celebrado en Vancouver (Canadá) del 7 al 11 de mayo.
Identifiersisbn: 978-1-909287-00-6
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(ICMA) Libros y partes de libros
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