English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/73747
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Peloruside A does not bind to the taxoid site on β-tubulin and retains its activity in multidrug-resistant cell lines

AuthorsGaitanos, Thomas N.; Martínez Buey, Rubén ; Díaz, José Fernando ; Northcote, Peter; Teesdale-Spittle, Paul; Andreu, José Manuel ; Miller, John H.
Issue Date2004
PublisherAmerican Association for Cancer Research
CitationCancer Research 64(15):5063-5067(2004)
AbstractPeloruside A (peloruside), a microtubule-stabilizing agent from a marine sponge, is less susceptible than paclitaxel to multidrug resistance arising from overexpression of the P-glycoprotein efflux pump and is not affected by mutations that affect the taxoid binding site of β-tubulin. In vitro studies with purified tubulin indicate that peloruside directly induces tubulin polymerization in the absence of microtubule-associated proteins. Competition for binding between peloruside, paclitaxel, and laulimalide revealed that peloruside binds to a different site on tubulin to paclitaxel. Moreover, laulimalide was able to displace peloruside, indicating that peloruside and laulimalide may compete for the same or overlapping binding sites. It was concluded that peloruside and laulimalide have binding properties that are distinct from other microtubule-stabilizing compounds currently under investigation.
URIhttp://hdl.handle.net/10261/73747
DOI10.1158/0008-5472.CAN-04-0771
Identifiersdoi: 10.1158/0008-5472.CAN-04-0771
issn: 0008-5472
e-issn: 1538-7445
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.