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Title

Chronic treatment with atypical neuroleptics induces striosomal FosB/ΔFosB expression in rats

AuthorsGrande, Cristina CSIC ORCID; Zhu, H.; Martín- Hernández, A. B.; Lee, M.; Ortiz, Óscar CSIC; Hiroi, N.; Moratalla, Rosario CSIC ORCID
Issue Date2004
PublisherElsevier
CitationBiological Psychiatry 55: 457-463 (2004)
AbstractBackground Studies have shown that neuroleptics regulate expression of the transcription factor FosB/ΔFosB in the striatum, including the accumbens and caudate-putamen; however, the striatum is also divided into another structural dimension, the striosome and matrix compartments. The precise distribution of FosB/ΔFosB induced by chronic neuroleptics in these striatal compartments is poorly understood. Methods Rats received either single acute injections or chronic injections of clozapine (0 or 20 mg/kg, intraperitoneally [IP]), olanzapine (0 or 5 mg/kg, IP), or haloperidol (0 or 1. 5 mg/kg, IP) for 25 days. The levels and compartmental distribution of FosB/ΔFosB were examined. Results Chronic clozapine induced clustered FosB/ΔFosB expression within striosomes of the caudate-putamen. This pattern was due to increased levels of FosB/ΔFosB in striosomes within the ventrolateral caudate-putamen and reduced levels of basal FosB/ΔFosB in the matrix in the entire caudate-putamen. In contrast, chronic haloperidol increased FosB/ΔFosB equally within the matrix and striosomes throughout the entire caudate-putamen. Chronic olanzapine induced an intermediate pattern. Conclusions The relative absence of FosB/ΔFosB expression in the matrix correlates with the lack of parkinsonism of atypical neuroleptics. Expression of FosB/ΔFosB in the matrix may contribute to parkinsonism of typical neuroleptics.
URIhttp://hdl.handle.net/10261/73641
DOI10.1016/j.biopsych.2003.08.008
Identifiersdoi: 10.1016/j.biopsych.2003.08.008
issn: 0006-3223
Appears in Collections:(IC) Artículos




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