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Metabolites and tissue distribution of resveratrol in the pig

AuthorsAzorín-Ortuño, María CSIC; Yáñez-Gascón, María J. CSIC; Vallejo, Fernando CSIC ORCID; Pallarés, Francisco J.; Larrosa, Mar CSIC ORCID; Lucas, Ricardo CSIC; Morales, Juan C.; Tomás Barberán, Francisco CSIC ORCID ; García-Conesa, María Teresa CSIC ORCID ; Espín de Gea, Juan Carlos CSIC ORCID
Issue Date2011
PublisherJohn Wiley & Sons
CitationMolecular Nutrition and Food Research 55: 1154- 1168 (2011)
AbstractScope: trans-Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism and tissue distribution of RES using the pig, a mammal physiologically close to humans. Methods and results: Forty-seven tissues, organs and fluids were analyzed 6h after intragastric RES administration (5.9mg/kg body weight) using HPLC-MS/MS. Twelve RES and seven dihydroresveratrol (DH-RES) metabolites were detected. DH-RES was the main metabolite in cecum, colon and rectum, whereas RES-3-O-glucuronide was the most abundant one in fluids and organs. Approximately 74.5% of the total RES administered was recovered in the form of RES, DH-RES and derived metabolites (65.1% along the gastrointestinal tract, 7.7% in urine, 1.2% in bile and 0.5% in organs). We report here, for the first time, the occurrence of RES ribosyl-sulfate derivative, DH-RES diglucuronide, DH-RES sulfoglucuronide and DH-RES disulfate as well as the metabolic profile of RES and DH-RES in the aorta, lymph, lymph node, ovaries, uterus, cerebellum, pancreas, urinary bladder tissue, fat and muscle. Conclusion: This study contributes to the clarification of the metabolism and tissue distribution of RES and could help to further understand the mechanisms underlying its effects. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Identifiersdoi: 10.1002/mnfr.201100140
issn: 1613-4125
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