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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/73551
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dc.contributor.authorRedondo, Miriam-
dc.contributor.authorPalomo, Valle-
dc.contributor.authorPérez, Daniel I.-
dc.contributor.authorMartín-Álvarez, Rocío-
dc.contributor.authorPérez, Concepción-
dc.contributor.authorPaul-Fernández, Nuria-
dc.contributor.authorConde, Santiago-
dc.contributor.authorMengod Los Arcos, Guadalupe-
dc.contributor.authorMartínez Gil, Ana-
dc.contributor.authorGil, Carmen-
dc.contributor.authorCampillo, Nuria E.-
dc.date.accessioned2013-04-04T07:45:44Z-
dc.date.available2013-04-04T07:45:44Z-
dc.date.issued2012-
dc.identifierdoi: 10.1021/cn300105c-
dc.identifierissn: 1948-7193-
dc.identifier.citationACS Chemical Neuroscience 3(10): 793-803 (2012)-
dc.identifier.urihttp://hdl.handle.net/10261/73551-
dc.descriptionEl pdf del artículo es el manuscrito de autor.-- et al.-
dc.description.abstractA neural network model has been developed to predict the inhibitory capacity of any chemical structure to be a phosphodiesterase 7 (PDE7) inhibitor, a new promising kind of drugs for the treatment of neurological disorders. The numerical definition of the structures was achieved using CODES program. Through the validation of this neural network model, a novel family of 5-imino-1,2,4-thiadiazoles (ITDZs) has been identified as inhibitors of PDE7. Experimental extensive biological studies have demonstrated the ability of ITDZs to inhibit PDE7 and to increase intracellular levels of cAMP. Among them, the derivative 15 showed a high in vitro potency with desirable pharmacokinetic profile (safe genotoxicity and blood brain barrier penetration). Administration of ITDZ 15 in an experimental autoimmune encephalomyelitis (EAE) mouse model results in a significant attenuation of clinical symptoms, showing the potential of ITDZs, especially compound 15, for the effective treatment of multiple sclerosis. © 2012 American Chemical Society.-
dc.description.sponsorshipThe authors gratefully acknowledge the financial support of Ministry of Science and Innovation (MICINN) projects nos. SAF2009-13015-C02-01, SAF2009-13015-C02-02, PI10-01874 and CTQ2009-07664; Instituto de Salud Carlos III (ISCiii) projects RD07/0060/0015 (RETICS program) and CIBERNED; Fundación Española para la Ciencia y la Tecnología (FECYT) project no. FCT-09-INC-0367; Programa de cooperación bilateral CSIC-Universidad de la República (2009UY0006).-
dc.language.isoeng-
dc.publisherAmerican Chemical Society-
dc.rightsopenAccess-
dc.titleIdentification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice-
dc.typeartículo-
dc.identifier.doi10.1021/cn300105c-
dc.relation.publisherversionhttp://dx.doi.org/10.1021/cn300105c-
dc.embargo.terms2013-10-18-
dc.date.updated2013-04-04T07:45:45Z-
dc.description.versionPeer Reviewed-
dc.identifier.pmid23077723-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypeartículo-
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