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Association analyses of single nucleotide polymorphisms in bovine stearoyl-CoA desaturase and fatty acid synthase genes with fatty acid composition in commercial cross-bred beef steers

AuthorsLi, C.; Aldai, Noelia ; Vinsky, M.; Dugan, M. E. R.; McAllister, T. A.
KeywordsFatty acid composition in beef cattle
Fatty acid synthase
Single nuceotide polymorphism
Stearoyl-CoA desaturase
Issue DateFeb-2012
CitationAnimal Genetics: Immunogenetics, Molecular Genetics and Functional Genomics 43(1) : 93-97 (2012)
AbstractTwo previously reported non-synonymous coding single nucleotide polymorphisms (SNPs) of bovine stearoyl-CoA desaturase (delta-9-desaturase) (SCD) (c.878C>T) and fatty acid synthase (FASN) (g:17924A>G) were assessed for their associations with 72 individual and 12 groups of fatty acids in brisket adipose tissue of 223 Canadian commercial cross-bred beef steers. It was found that the ‘CC’ genotype of the SCD SNP was significantly associated with lower concentrations of saturated fatty acids (SFA) including 10:0, 14:0 and 20:0, higher concentrations of monounsaturated fatty acids including 9c-14:1, 12c-16:1 and 13c-18:1, higher concentrations of polyunsaturated fatty acids (PUFA) including 9c,15c-18:2, 10c,12c-18:2, 11c,13t-18:2 and 12c,14t-18:2, but lower concentrations of other PUFA of 9c,13t/8t,12c and 20:2n-6 (P < 0.05). The ‘AA’ genotype of the FASN SNP was significantly associated with higher concentrations of SFAs of 10:0, 12:0, 13:0, 14:0 and 15:0, lower concentrations of unsaturated fatty acids of 9c-18:1 and 20:3n-6, and higher concentrations of unsaturated fatty acids of 9c-14:1 and 12c-16:1 (P < 0.05). Significant epistatic effects between the SCD and FASN SNP genotypes were also found for several fatty acids including 10:0, 23:0, 6t/7t/8t-18:1, 12t-18:1, 13t/14t-18:1, 16t-18:1, total trans18:1 and 9c,13t/8t,12c-18:2 (P < 0.05). These results further suggest that SCD and FASN are strong candidate genes influencing fatty acid composition in beef cattle.
Description5 páginas, 3 tablas.
Publisher version (URL)http://dx.doi.org/10.1111/j.1365-2052.2011.02217.x
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