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The cyclopentenone 15-deoxy-D-12,14-Prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer´s disease patients

AuthorsMuñoz, Úrsula ; De las Cuevas, Natividad; Bartolomé Robledo, Fernando ; García-Hermida, Ofelia; Bermejo-Pareja, Félix; Martín-Requero, Ángeles
KeywordsAlzheimer's disease
Cell cycle
Issue DateOct-2005
CitationExperimental Neurology, 195 (2) : 508-517 (2005)
AbstractEpidemiologic studies indicated that non-steroidal anti-inflammatory drugs (NSAIDs) might prevent or delay the clinical features of Alzheimer disease (AD). The pharmacological activity of NSAIDs is generally attributed to inhibition of cyclooxygenase and peroxisome proliferator-activated receptor γ (PPARγ) activation. Based on the antineoplastic and apoptotic effects of PPARγ activation in a number of cell types, we hypothesized that NSAIDs could protect neurons by controlling the regulation of cell cycle. Recent work suggests that uncoordinated expression of cell cycle molecules and perturbation of cell cycle checkpoints may be one of the mechanisms by which post-mitotic neurons die. Since cell cycle dysfunction is not restricted to neurons in AD, we found it interesting to study the role of PPARγ activation on cell proliferation in immortalized lymphocytes from AD patients. We report here that 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), but not NSAIDs or thiazolidinediones inhibited the serum-mediated enhancement of cell proliferation in AD by blocking the events critical for G1/S transition. The cyclopentenone induced a partial inhibition of retinoblastoma protein phosphorylation and increased levels of the CDK inhibitor p27kip1
Description10 páginas, 9 figuras -- PAGS nros. 508-517
Publisher version (URL)http://dx.doi.org/10.1016/j.expneurol.2005.06.010
Appears in Collections:(CIB) Artículos
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