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http://hdl.handle.net/10261/73387
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Fernaud-Espinosa, Isabel | - |
dc.contributor.author | Nieto-Sampedro, Manuel | - |
dc.contributor.author | Bovolenta, Paola | - |
dc.date.accessioned | 2013-04-02T11:26:02Z | - |
dc.date.available | 2013-04-02T11:26:02Z | - |
dc.date.issued | 1998 | - |
dc.identifier | doi: 10.1002/(SICI)1097-4695(199807)36:1<16::AID-NEU2>3.0.CO;2-D | - |
dc.identifier | issn: 0022-3034 | - |
dc.identifier.citation | Journal of Neurobiology 36: 16-29 (1998) | - |
dc.identifier.uri | http://hdl.handle.net/10261/73387 | - |
dc.description.abstract | The expression of proteoglycans (PGs) in the mammalian central nervous system (CNS) appears to be strictly regulated both during development and after damage to the mammalian CNS. Recently, we have isolated from membranes of injured adult brain a neurite outgrowth-inhibitory proteoglycan (IMP), the activity of which could be specifically counteracted by a monoclonal antibody (mAB) against the PG. We described in this report the characterization of perinatal membrane proteoglycan (PMP), a heparan-sulfate/chondroitin-sulfate- containing PG expressed during brain development. Its maximal expression was observed around postnatal day 3, decreasing strongly in normal adult tissue. This PG was purified and characterized using mABs generated against IMP. The comparison of PMP and IMP properties indicates that the two PGs are highly related and share expression patterns, biochemical characteristics, and the ability to inhibit neurite initiation in culture. However, IMP and PMP displayed a distinct effect on neurite elongation, which may be explained by their differences in glycosilation pattern. The data presented in this report support the idea that proteoglycans expressed during CNS development are re- expressed following injury. | - |
dc.language.iso | eng | - |
dc.publisher | John Wiley & Sons | - |
dc.rights | closedAccess | - |
dc.title | A neurite outgrowth-inhibitory proteoglycan expressed during development is similar to that isolated from adult brain after isomorphic injury | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1002/(SICI)1097-4695(199807)36:1<16::AID-NEU2>3.0.CO;2-D | - |
dc.date.updated | 2013-04-02T11:26:02Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
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