Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/73000
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Cloning, chromosome mapping and expression analysis of the HIRA gene from Drosophila melanogaster |
Autor: | Llevadot, R.; Marqués, G.; Pritchard, Melanie; Estivill, Xavier CSIC; Ferrús, Alberto CSIC ORCID; Scambler, Peter | Fecha de publicación: | 1998 | Editor: | Academic Press | Citación: | Biochemical and Biophysical Research Communications 249: 486-491 (1998) | Resumen: | The human HIRA gene was identified as a putative transcriptional regulator mapping within the Di-George syndrome critical region at 22q11. HIRA-related proteins have been described in a number of species, but functional information concerning family members is only available in Saccharomyces cerevisiae, where the Hir1p and Hir2p proteins are known to be transcriptional corepressors. In order to analyse conservation of HIRA-related genes and to provide resources for functional studies in another model organism we have isolated the HIRA gene from Drosophila melanogaster (dhira). The 3374 nucleotide cDNA encodes a protein of 1047 aa, showing 42% identity with the human protein. Alignment with the predicted HIRA proteins from human, mouse, chick and pufferfish reveals strong conservation within the N-terminal region which contains seven WD domains, with less conservation of C-terminal sequences. In situ hybridisation to salivary gland chromosomes indicates that the gene resides in region 7B2-3 of the X chromosome. Dhira is expressed through embryonic development and at lower levels during larval and pupal development. The expression of dhira is dramatically increased in early embryos and in females, suggesting that the dhira mRNA could be maternally deposited in the embryos. | URI: | http://hdl.handle.net/10261/73000 | DOI: | 10.1006/bbrc.1998.9165 | Identificadores: | doi: 10.1006/bbrc.1998.9165 issn: 0006-291X |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
9
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
9
checked on 23-feb-2024
Page view(s)
264
checked on 23-abr-2024
Download(s)
99
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.