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Título: | Balance of pro-apoptotic TGF-ß and anti-apoptotic insulin effects in the control of cell death in the postnatal mouse retina |
Autor: | Duenker, N.; Valenciano, Ana I. CSIC ORCID; Franke, Andre; Hernández-Sánchez, Catalina ; Dressel, R.; Behrendt, M.; Krieglstein, K.; De la Rosa, Enrique J. CSIC ORCID | Palabras clave: | Apoptosis BCL-2 Caspases Smad Transforming growth factor-β receptor Transforming growth factor-induced immediate-early gene |
Fecha de publicación: | jul-2005 | Editor: | Wiley-Blackwell | Citación: | European Journal of Neuroscience 22(1):28-38 | Resumen: | Transforming growth factor (TGF)-β and insulin display opposite effects in regulating programmed cell death during vertebrate retina development; the former induces apoptosis while the latter prevents it. In the present study we investigated coordinated actions of TGF-β and insulin in an organotypic culture system of early postnatal mouse retina. Addition of exogenous TGF-β resulted in a significant increase in cell death whereas exogenous insulin attenuated apoptosis and was capable of blocking TGF-β-induced apoptosis. This effect appeared to be modulated via insulin-induced transcriptional down-regulation of TGF-β receptor II levels. The analysis of downstream signalling molecules also revealed opposite effects of both factors; insulin provided survival signalling by increasing the level of anti-apoptotic Bcl-2 protein expression and phosphorylation and down-regulating caspase 3 activity whereas pro-apoptotic TGF-β signalling reduced Bcl-2 mRNA levels and Bcl-2 phosphorylation and induced the expression of TGF-induced immediate-early gene (TIEG), a Krüppel-like zinc-finger transcription factor, mimicking TGF-β activity | Descripción: | 11 páginas, 9 figuras -- PAGS nros. 28-38 | Versión del editor: | http://dx.doi.org/10.1111/j.1460-9568.2005.04183.x | URI: | http://hdl.handle.net/10261/72938 | DOI: | 10.1111/j.1460-9568.2005.04183.x | ISSN: | 0953-816X | E-ISSN: | 1460-9568 |
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