English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/72899
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Varicose veins show enhanced chemokine expression

AuthorsRio Solá, Luis del; Aceves, Mónica ; Dueñas, Ana I. ; Sánchez Crespo, Mariano; García-Rodríguez, Carmen
Issue Date2009
PublisherElsevier
CitationEuropean Journal of Vascular and Endovascular Surgery 38(5): 635-641 (2009)
Abstract[Objectives]: Leucocyte infiltration in the wall of varicose veins has been reported previously. This study was designed to investigate the expression of pro-inflammatory cytokines and chemokines in control and in patients with varicose veins and to test the effect of treating varicose vein patients with acetylsalicylic acid (ASA) on cytokine expression prior to removal of varices. [Material and methods]: Sections of vein were removed during operation from both patient groups, and ribonuclease protection assays (RPAs) were performed to assess the expression of chemokines. Group I included non-varicose saphenous veins from healthy patients undergoing amputation for trauma. Varicose veins were obtained from patients with primary varicose undergoing surgical treatment who received no drug (group II) or treatment with 300 mg day-1 of ASA for 15 days before surgery (group III). [Results]: Non-varicose veins constitutively expressed low levels of monocyte-chemoattractant protein (MCP-1) and interleukin (IL)-8 mRNA. Varicose veins had a distinct chemokine expression pattern, since significant up-regulation of MCP-1 and IL-8 and a marked expression of IP-10, RANTES, MIP-1α and MIP-1β mRNA were detected. Removal of the endothelium did not alter this pattern. Varicose veins obtained from patients treated with ASA showed a consistent decrease in chemokine expression, although it did not reach statistical significance. [Conclusions]: Varicose veins showed increased expression of several chemokines compared to control veins. A non-significant reduction of activation was observed following treatment with ASA for 15 days. © 2009.
URIhttp://hdl.handle.net/10261/72899
DOI10.1016/j.ejvs.2009.07.021
Identifiersdoi: 10.1016/j.ejvs.2009.07.021
issn: 1078-5884
Appears in Collections:(IBGM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.