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http://hdl.handle.net/10261/72763
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Nowakowski, Adam | - |
dc.contributor.author | Alonso-Martín, Sonia | - |
dc.contributor.author | González-Manchón, Consuelo | - |
dc.contributor.author | Larrucea, Susana | - |
dc.contributor.author | Fernández, Darío | - |
dc.contributor.author | Vilar-Egea, Maripaz | - |
dc.contributor.author | Cerdán, Sebastián | - |
dc.contributor.author | Sánchez Ayuso, Matilde | - |
dc.contributor.author | Parrilla, Roberto L. | - |
dc.date.accessioned | 2013-03-22T12:22:55Z | - |
dc.date.available | 2013-03-22T12:22:55Z | - |
dc.date.issued | 2010 | - |
dc.identifier | doi: 10.1016/j.mcn.2009.09.011 | - |
dc.identifier | issn: 1044-7431 | - |
dc.identifier.citation | Molecular and Cellular Neurosciences 43(1):90-97(2010) | - |
dc.identifier.uri | http://hdl.handle.net/10261/72763 | - |
dc.description.abstract | Podocalyxin (Podxl) is a type I membrane mucin-protein of the CD34 family abundantly expressed in kidney epithelial cells (podocytes) where it plays a crucial functional role. Podxl is also expressed in tissues other than kidney, like in brain, but its function is ignored. To investigate the functional role of podocalyxin (Podxl) in brain we produced the specific brain-ablation of the Podxl gen in mice by crossing Podxlfloxed/floxed mice, generated in our laboratory, to mice with pan-neural expression of recombinase Cre (Cre3). Podxl-/- mice show no apparent behavioral phenotype but their brains showed enlargement of ventricular volumes detected in vivo by MR imaging. The pattern of brain vasculature was of normal appearance but the thickness of the main carotid artery was significantly increased. Moreover, the histological analysis showed increased number of choroidal capillaries lining the ventricular spaces. These findings are analyzed in the light of the role likely played by podocalyxin in cell migration and cell-cell recognition during brain development and also on the consistent findings of increased ventricular spaces in human pathological disorders like schizophrenia. © 2009 Elsevier Inc. All rights reserved. | - |
dc.description.sponsorship | Adam Nowakowski holds a research predoctoral contract from de CIBERER. Sonia Alonso-Martín was recipient of a predoctoral fellowship from the Basque Community (BF101-40). This work was supported in part by grants from the Spanish Ministry of Science and Innovation (SAF 2004-04345, SAF2005-01261 and SAF2007-61701). The CIBER de Enfermedades Raras (CIBERER) is an initiative of the ISCIII. | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.rights | closedAccess | - |
dc.title | Ventricular enlargement associated with the panneural ablation of the podocalyxin gene | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.mcn.2009.09.011 | - |
dc.date.updated | 2013-03-22T12:22:56Z | - |
dc.description.version | Peer Reviewed | - |
dc.contributor.funder | Federación Española de Enfermedades Raras | - |
dc.contributor.funder | Eusko Jaurlaritza | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002924 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003086 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (IIBM) Artículos (CIB) Artículos |
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