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Cortical microarchitecture alterations in Ts65Dn mice, an animal model for Down Syndrome: Impact of environmental enrichment | Alteraciones de la microarquitectura de la corteza cerebral en el ratón Ts65Dn, un modelo murino de síndrome de Down: Efectos del enriquecimiento ambiental

AuthorsDierssen, M.; Benavides-Piccione, Ruth CSIC ORCID; Ballesteros-Yáñez, Inmaculada; Martínez-Cué, Carmen; Estivill, X.; Flórez, Jesús; Elston, G. N.; DeFelipe, Javier
Issue Date2003
CitationSD Revista Medica Internacional sobre el Sindrome de Down 7: 18-25 (2003)
AbstractDown syndrome (DS) is the most common genetic disorder associated with mental retardation, affecting 1 in 1000 newborn children in Europe. Studies of DS population provide a rare opportunity to examine relationships between cognition, genotype and brain neurobiology, allowing comparisons across these different levels of analysis. The crucial question is to define how do excess of normal gene products in interaction with the environment, direct and constrain neural maturation and how does this maldevelopment translate into mind and behavior. Although mental retardation likely involves anatomical, chemical and neurophysiological brain abnormalities, the mechanisms by which subnormal intelligence during development arise from these abnormalities are difficult to discern. Dendritic abnormalities are the most consistent anatomical correlates of mental retardation. Earliest descriptions of dendritic pathology in DS included dendritic spine dysgenesis, and dendritic anomalies involving branches. Dendritic abnormalities appear to have specific consequences in the pathogenesis and evolution of DS brains, which correlate to some extent with the cognitive profile. The cortical microarchitecture of animal models and the impact of environmental enrichment on the phenotype, centered in dendritic abnormalities and plasticity, is analyzed.
Identifiersissn: 1138-011X
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