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dc.contributor.authorBartolomé Robledo, Fernando-
dc.contributor.authorMuñoz, Úrsula-
dc.contributor.authorEsteras, Noemí-
dc.contributor.authorEsteban, Jesús-
dc.contributor.authorBermejo-Pareja, Félix-
dc.contributor.authorMartín-Requero, Ángeles-
dc.date.issued2009-12-01-
dc.identifier.citationInternational Journal of Clinical and Experimental Pathology 2(4) : 390-398 (2009)es_ES
dc.identifier.issn1936-2625-
dc.identifier.urihttp://hdl.handle.net/10261/72378-
dc.description9 páginas, 6 figuras, 1 tabla -- PAGS nros. 390-398es_ES
dc.description.abstractAlterations in cell cycle progression seem to be associated with neuronal death in Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). We previously reported disturbances in the control of cell survival/death fate in immortalized lymphocytes from AD patients. These cell cycle dysfunction and impaired apoptosis were considered systemic manifestations of AD disease. The purpose of this study was to evaluate whether these abnormalities are characteristic of AD, or they may be seen in other neurodegenerative disorders such ALS. Our results indicate that alterations in signaling molecules, Akt and ERK1/2, and in the cyclin-dependent kinase complex inhibitors (CDKis) p21Cip1 and p27Kip1 are detectable in lymphoblasts from AD patients, but not in ALS patients, suggesting that these variables may be considered for the development of biomarkers of AD. However, lymphocytes from ALS patients do not represent a useful model to study cell cycle-related events associated with neurodegeneration of motoneuronses_ES
dc.description.sponsorshipThis work has been supported by grants from the Spanish Ministry of Science and Innovation (SAF2007-62405) and Fundación Rodríguez Pascual. NE holds a fellowship of the JAE predoctoral program of the CSICes_ES
dc.language.isoenges_ES
dc.publishere-Century Publishinges_ES
dc.rightsopenAccesses_ES
dc.subjectAlzheimer’s diseasees_ES
dc.subjectAmyotrophic lateral sclerosises_ES
dc.subjectLymphocyteses_ES
dc.subjectCell proliferationes_ES
dc.subjectApoptosises_ES
dc.subjectP21es_ES
dc.subjectP27es_ES
dc.subjectPI3K/Aktes_ES
dc.subjectERK1/2es_ES
dc.titleDistinct regulation of cell cycle and survival in lymphocytes from patients with Alzheimer´s disease and amyotrophic lateral sclerosises_ES
dc.typeartículoes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.identifier.e-issn1936-2625-
dc.identifier.pmid19158936-
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